Breakthroughs, discoveries, and DIY tips sent every weekday. Oyster larvae that grow in water with traces of common drugs such as cocaine, ketamine, and fentanyl are slower swimmers that appear more stressed. This new research indicates that the common drugs do have an effect on oyster larvae that are found in contaminated water. The results were presented this week at the Society for Risk Analysis' annual conference and published in the journal All sorts of pharmaceuticals, from pain relievers to illegal drugs, can make it into the water supply via human excretion, manufacturing plants, or if they are flushed down the toilet . While that water does go through wastewater treatment, pharmaceuticals can pass right through.

This work presents the development and evaluation of an NLP-enabled probabilistic classifier designed to estimate the probability of technical and regulatory success (pTRS) for clinical trials in the field of neuroscience. While pharmaceutical R&D is plagued by high attrition rates and enormous costs, particularly within neuroscience, where success rates are below 10%, timely identification of promising programs can streamline resource allocation and reduce financial risk. Leveraging data from the ClinicalTrials.gov database and success labels from the recently developed Clinical Trial Outcome dataset, the classifier extracts text-based clinical trial features using statistical NLP techniques. These features were integrated into several non-LLM frameworks (logistic regression, gradient boosting, and random forest) to generate calibrated probability scores. Model performance was assessed on a retrospective dataset of 101,145 completed clinical trials spanning 1976-2024, achieving an overall ROC-AUC of 0.64. An LLM-based predictive model was then built using BioBERT, a domain-specific language representation encoder. The BioBERT-based model achieved an overall ROC-AUC of 0.74 and a Brier Score of 0.185, indicating its predictions had, on average, 40% less squared error than would be observed using industry benchmarks. The BioBERT-based model also made trial outcome predictions that were superior to benchmark values 70% of the time overall. By integrating NLP-driven insights into drug development decision-making, this work aims to enhance strategic planning and optimize investment allocation in neuroscience programs.

Urban traffic congestion, particularly at intersections, significantly affects travel time, fuel consumption, and emissions. Traditional fixed-time signal control systems often lack the adaptability to effectively manage dynamic traffic patterns. This study explores the application of multi-agent reinforcement learning (MARL) to optimize traffic signal coordination across multiple intersections within a simulated environment. A simulation was developed to model a network of interconnected intersections with randomly generated vehicle flows to reflect realistic traffic variability. A decentralized MARL controller was implemented in which each traffic signal operates as an autonomous agent, making decisions based on local observations and information from neighboring agents. Performance was evaluated against a baseline fixed-time controller using metrics such as average vehicle wait time and overall throughput. The MARL approach demonstrated statistically significant improvements, including reduced average waiting times and improved throughput. These findings suggest that MARL-based dynamic control strategies hold substantial promise to improve urban traffic management efficiency. More research is recommended to address the challenges of scalability and real-world implementation.

Multimodal trajectory prediction generates multiple plausible future trajectories to address vehicle motion uncertainty from intention ambiguity and execution variability. However, HD map-dependent models suffer from costly data acquisition, delayed updates, and vulnerability to corrupted inputs, causing prediction failures. Map-free approaches lack global context, with pairwise attention over-amplifying straight patterns while suppressing transitional patterns, resulting in motion-intention misalignment. This paper proposes GContextFormer, a plug-and-play encoder-decoder architecture with global context-aware hybrid attention and scaled additive aggregation achieving intention-aligned multimodal prediction without map reliance. The Motion-Aware Encoder builds scene-level intention prior via bounded scaled additive aggregation over mode-embedded trajectory tokens and refines per-mode representations under shared global context, mitigating inter-mode suppression and promoting intention alignment. The Hierarchical Interaction Decoder decomposes social reasoning into dual-pathway cross-attention: a standard pathway ensures uniform geometric coverage over agent-mode pairs while a neighbor-context-enhanced pathway emphasizes salient interactions, with gating module mediating their contributions to maintain coverage-focus balance. Experiments on eight highway-ramp scenarios from TOD-VT dataset show GContextFormer outperforms state-of-the-art baselines. Compared to existing transformer models, GContextFormer achieves greater robustness and concentrated improvements in high-curvature and transition zones via spatial distributions. Interpretability is achieved through motion mode distinctions and neighbor context modulation exposing reasoning attribution. The modular architecture supports extensibility toward cross-domain multimodal reasoning tasks. Source: https://fenghy-chen.github.io/sources/.

Bayesian Networks (BNs) are an important tool for assisting probabilistic reasoning, but despite being considered transparent models, people have trouble understanding them. Further, current User Interfaces (UIs) still do not clarify the reasoning of BNs. To address this problem, we have designed verbal and visual extensions to the standard BN UI, which can guide users through common inference patterns. We conducted a user study to compare our verbal, visual and combined UI extensions, and a baseline UI. Our main findings are: (1) users did better with all three types of extensions than with the baseline UI for questions about the impact of an observation, the paths that enable this impact, and the way in which an observation influences the impact of other observations; and (2) using verbal and visual modalities together is better than using either modality alone for some of these question types.

We present OpenRoboCare, a multimodal dataset for robot caregiving, capturing expert occupational therapist demonstrations of Activities of Daily Living (ADLs). Caregiving tasks involve complex physical human-robot interactions, requiring precise perception under occlusions, safe physical contact, and long-horizon planning. While recent advances in robot learning from demonstrations have shown promise, there is a lack of a large-scale, diverse, and expert-driven dataset that captures real-world caregiving routines. To address this gap, we collect data from 21 occupational therapists performing 15 ADL tasks on two manikins. The dataset spans five modalities: RGB-D video, pose tracking, eye-gaze tracking, task and action annotations, and tactile sensing, providing rich multimodal insights into caregiver movement, attention, force application, and task execution strategies. We further analyze expert caregiving principles and strategies, offering insights to improve robot efficiency and task feasibility. Additionally, our evaluations demonstrate that OpenRoboCare presents challenges for state-of-the-art robot perception and human activity recognition methods, both critical for developing safe and adaptive assistive robots, highlighting the value of our contribution. See our website for additional visualizations: https://emprise.cs.cornell.edu/robo-care/.

The advent of multimodal deep learning models, such as CLIP, has unlocked new frontiers in a wide range of applications, from image-text understanding to classification tasks. However, these models are not safe for adversarial attacks, particularly backdoor attacks, which can subtly manipulate model behavior. Moreover, existing defense methods typically involve training from scratch or fine-tuning using a large dataset without pinpointing the specific labels that are affected. In this study, we introduce an innovative strategy to enhance the robustness of multimodal contrastive learning models against such attacks. In particular, given a poisoned CLIP model, our approach can identify the backdoor trigger and pinpoint the victim samples and labels in an efficient manner. To that end, an image segmentation ``oracle'' is introduced as the supervisor for the output of the poisoned CLIP. We develop two algorithms to rectify the poisoned model: (1) differentiating between CLIP and Oracle's knowledge to identify potential triggers; (2) pinpointing affected labels and victim samples, and curating a compact fine-tuning dataset. With this knowledge, we are allowed to rectify the poisoned CLIP model to negate backdoor effects. Extensive experiments on visual recognition benchmarks demonstrate our strategy is effective in CLIP-based backdoor defense.

Inspired by the dual-process theory of human cognition from \textit{Thinking, Fast and Slow}, we introduce \textbf{PRIME} (Planning and Retrieval-Integrated Memory for Enhanced Reasoning), a multi-agent reasoning framework that dynamically integrates \textbf{System 1} (fast, intuitive thinking) and \textbf{System 2} (slow, deliberate thinking). PRIME first employs a Quick Thinking Agent (System 1) to generate a rapid answer; if uncertainty is detected, it then triggers a structured System 2 reasoning pipeline composed of specialized agents for \textit{planning}, \textit{hypothesis generation}, \textit{retrieval}, \textit{information integration}, and \textit{decision-making}. This multi-agent design faithfully mimics human cognitive processes and enhances both efficiency and accuracy. Experimental results with LLaMA 3 models demonstrate that PRIME enables open-source LLMs to perform competitively with state-of-the-art closed-source models like GPT-4 and GPT-4o on benchmarks requiring multi-hop and knowledge-grounded reasoning. This research establishes PRIME as a scalable solution for improving LLMs in domains requiring complex, knowledge-intensive reasoning.

The Contrastive Language-Image Pretraining (CLIP) model has significantly advanced vision-language modeling by aligning image-text pairs from large-scale web data through self-supervised contrastive learning. Yet, its reliance on uncurated Internet-sourced data exposes it to data poisoning and backdoor risks. While existing studies primarily investigate image-based attacks, the text modality, which is equally central to CLIP's training, remains underexplored. In this work, we introduce ToxicTextCLIP, a framework for generating high-quality adversarial texts that target CLIP during the pre-training phase. The framework addresses two key challenges: semantic misalignment caused by background inconsistency with the target class, and the scarcity of background-consistent texts. To this end, ToxicTextCLIP iteratively applies: 1) a background-aware selector that prioritizes texts with background content aligned to the target class, and 2) a background-driven augmenter that generates semantically coherent and diverse poisoned samples. Extensive experiments on classification and retrieval tasks show that ToxicTextCLIP achieves up to 95.83% poisoning success and 98.68% backdoor Hit@1, while bypassing RoCLIP, CleanCLIP and SafeCLIP defenses. The source code can be accessed via https://github.com/xinyaocse/ToxicTextCLIP/.

To date, there exist almost no culturally-specific evaluation benchmarks for large language models (LLMs) that cover a large number of languages and cultures. In this paper, we present Global PIQA, a participatory commonsense reasoning benchmark for over 100 languages, constructed by hand by 335 researchers from 65 countries around the world. The 116 language varieties in Global PIQA cover five continents, 14 language families, and 23 writing systems. In the non-parallel split of Global PIQA, over 50% of examples reference local foods, customs, traditions, or other culturally-specific elements. We find that state-of-the-art LLMs perform well on Global PIQA in aggregate, but they exhibit weaker performance in lower-resource languages (up to a 37% accuracy gap, despite random chance at 50%). Open models generally perform worse than proprietary models. Global PIQA highlights that in many languages and cultures, everyday knowledge remains an area for improvement, alongside more widely-discussed capabilities such as complex reasoning and expert knowledge. Beyond its uses for LLM evaluation, we hope that Global PIQA provides a glimpse into the wide diversity of cultures in which human language is embedded.